Hard disk sentinel pro v4.40.9 key2/18/2023 ![]() ![]() Its intracellular functions are diverse as it acts as a signalling protein, a transcription factor but also participates in mitochondria energy production and protection. ItÕs regulated by multiple receptor systems, which are coupled to positive and negative feedback loops to ensure physiological and beneficial action. STAT3 activity depends on multiple posttranslational modifications (phosphorylation, acetylation, dimerization). The signal transducer and activator of transcription 3 (STAT3) is fundamental for physiological homeostasis and stress-induced remodelling of the heart as deregulated STAT3 circuits are sufficient to induce dilated- and peripartum cardiomyopathy and adverse remodelling after myocardial infarction.
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